Mode of Action — let’s take a closer look

In a knee affected by OA, the synovium plays a central role in both acute and chronic disease.. Mechanical signalling (via mechanoreceptors) and chemical signalling (e.g. cytokines) drive OA progression and create a cycle of inflammation and damage. Synovial inflammation, triggered by factors such as trauma or overuse, leads to a fibrotic and inelastic synovial…